A strong immune system is crucial for a cat’s ability to resist infections, recover from illnesses, and maintain overall health. While genetics and age play roles in feline immunity, several proven strategies can help strengthen a cat’s immune defenses. These strategies range from dietary adjustments and supplementation to lifestyle factors such as stress reduction and veterinary care. One supplement of particular interest is lysine, an amino acid often discussed in the context of feline upper respiratory health.
1. Balanced Nutrition
A well-balanced diet rich in high-quality proteins, essential fatty acids, and vitamins is the foundation of a healthy immune system. Cats are obligate carnivores and require amino acids such as taurine and arginine, which are vital for immune function (Case et al., 2011). Additionally, antioxidants such as vitamins C and E help reduce oxidative stress, which can impair immune responses.
2. Supplementation with Lysine
Lysine is an essential amino acid that has been widely used in feline medicine, particularly for managing feline herpesvirus type-1 (FHV-1), a common cause of upper respiratory infections in cats. Lysine is believed to inhibit viral replication by competing with arginine, another amino acid required for the herpesvirus to replicate (Rees & Lubinski, 2008). However, recent research has challenged the efficacy of lysine supplementation.

In a systematic review, Drazenovich et al. (2017) concluded that lysine does not significantly reduce the frequency or severity of FHV-1 symptoms and may, in some cases, be counterproductive. Despite this, lysine continues to be used by some veterinarians as part of a broader immune support strategy, particularly when cats show individual improvements.
3. Probiotics and Gut Health
Emerging research supports the connection between gut health and immune function in cats. Probiotic supplementation can enhance the intestinal microbiome, promoting better digestion and systemic immunity (Marshall-Jones et al., 2006). Specific strains such as Enterococcus faecium and Lactobacillus acidophilus have been shown to support immune responses in cats and kittens.
4. Minimizing Stress
Chronic stress can suppress immune function and make cats more susceptible to illness. Providing a stable environment, regular routines, enrichment activities, and safe spaces for hiding or climbing can help reduce stress (Amat et al., 2016). Pheromone diffusers and behavior therapy may also assist in stress management.
5. Regular Veterinary Care and Vaccinations
Routine veterinary visits allow for early detection of potential health issues and ensure that cats receive timely vaccinations and parasite prevention. Vaccines stimulate the immune system to prepare for potential exposure to pathogens, reducing the risk of serious infections (Day et al., 2016).
Conclusion
Maintaining a strong immune system in cats involves a multifaceted approach that includes nutrition, environmental management, and medical care. While lysine has been commonly used as a supplement for feline viral infections, current research questions its efficacy. As with any health strategy, cat owners should consult with veterinarians to develop a tailored plan suited to their cat’s individual needs.
References
Amat, M., Camps, T., & Manteca, X. (2016). Stress in owned cats: behavioural changes and welfare implications. Journal of Feline Medicine and Surgery, 18(8), 577-586. https://doi.org/10.1177/1098612X15590867
Case, L. P., Daristotle, L., Hayek, M. G., & Raasch, M. F. (2011). Canine and feline nutrition: A resource for companion animal professionals (3rd ed.). Elsevier Health Sciences.
Day, M. J., Horzinek, M. C., & Schultz, R. D. (2016). WSAVA guidelines for the vaccination of dogs and cats. Journal of Small Animal Practice, 57(1), E1–E45. https://doi.org/10.1111/jsap.2_12431
Drazenovich, T. L., Fascetti, A. J., & Westermeyer, H. D. (2017). Lysine supplementation is not effective for the prevention or treatment of feline herpesvirus 1 infection in cats: A systematic review. BMC Veterinary Research, 13(1), 1–9. https://doi.org/10.1186/s12917-017-0984-5
Marshall-Jones, Z. V., Baillon, M. L. A., Croft, J. M., & Butterwick, R. F. (2006). Effects of Lactobacillus acidophilus DSM13241 as a probiotic in healthy adult cats. American Journal of Veterinary Research, 67(6), 1005–1012. https://doi.org/10.2460/ajvr.67.6.1005
Rees, T. M., & Lubinski, J. L. (2008). Effects of L-lysine on feline herpesvirus type 1 and feline calicivirus replication in vitro. American Journal of Veterinary Research, 69(2), 161–165. https://doi.org/10.2460/ajvr.69.2.161